Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 6/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MDH1 | P40925 | 1/20 | 0.38 |
| ▸ | MDH2 | P40926 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452612 | 0.95 | MAPT (0.46) | MAPTALOX15TAS2R14EPHX2RXFP1 | |
| SCHEMBL22452617 | 0.85 | TAS2R14 (0.44) | MAPTALOX15TAS2R14EPHX2RXFP1 | |
| SCHEMBL22452492 | 0.85 | TAS2R14 (0.56) | TAS2R14EPHX2RXFP1ADRA2BADRA2C | |
| SCHEMBL22452614 | 0.84 | EPHX2 (0.41) | TAS2R14EPHX2LMNAMDH1MDH2 | |
| SCHEMBL22452503 | 0.84 | MAPT (0.58) | MAPTALOX15EPHX2LMNAMDH1 | |
| SCHEMBL22452501 | 0.83 | MAPT (0.55) | MAPTALOX15EPHX2MDH1MDH2 | |
| SCHEMBL22452848 | 0.83 | MAPT (0.49) | MAPTALOX15EPHX2LMNAMDH1 | |
| SCHEMBL22452620 | 0.81 | CNR2 (0.51) | MAPTEPHX2LMNACYP1A2CYP2C9 | |
| SCHEMBL22452615 | 0.81 | NPC1 (0.40) | EPHX2MDH1MDH2NPC1HIF1A | |
| SCHEMBL22452652 | 0.78 | EPHX2 (0.61) | MAPTALOX15EPHX2LMNAMDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |