Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 3/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452488 | 0.85 | SERPINE1 (0.64) | DHODHSERPINE1CASP3SENP8SENP7 | |
| SCHEMBL22453629 | 0.82 | SERPINE1 (0.48) | DHODHSERPINE1MEN1KMT2APKM | |
| SCHEMBL22453805 | 0.80 | SERPINE1 (0.51) | DHODHSERPINE1MEN1KMT2AHIF1A | |
| SCHEMBL22453626 | 0.79 | SERPINE1 (0.65) | DHODHSERPINE1CASP3SENP8SENP7 | |
| SCHEMBL22452527 | 0.78 | SERPINE1 (0.57) | DHODHSERPINE1CASP3SENP8SENP7 | |
| SCHEMBL22453497 | 0.78 | SERPINE1 (0.57) | DHODHSERPINE1CASP3SENP8SENP7 | |
| SCHEMBL22452754 | 0.76 | SERPINE1 (0.58) | SERPINE1MEN1KMT2APKMHIF1A | |
| SCHEMBL22453292 | 0.76 | SERPINE1 (0.58) | DHODHSERPINE1MEN1KMT2APKM | |
| SCHEMBL22452715 | 0.76 | SERPINE1 (0.64) | DHODHSERPINE1MEN1KMT2APKM | |
| SCHEMBL22453268 | 0.73 | EPHX2 (0.55) | MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |