Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453153 | 0.91 | TDP1 (0.47) | HIF1AEPAS1 | |
| SCHEMBL22453641 | 0.87 | DHODH (0.55) | HIF1AEPAS1SERPINE1NPC1ALDH1A1 | |
| SCHEMBL22453075 | 0.84 | DHODH (0.49) | HIF1AEPAS1NPC1ALDH1A1HTT | |
| SCHEMBL22452782 | 0.82 | SERPINE1 (0.42) | HIF1AEPAS1SERPINE1NPC1ALDH1A1 | |
| SCHEMBL22453269 | 0.82 | SERPINE1 (0.42) | HIF1AEPAS1SERPINE1NPC1RAB9A | |
| SCHEMBL22453640 | 0.82 | DHODH (0.57) | HIF1AEPAS1SERPINE1NPC1RAB9A | |
| SCHEMBL22452486 | 0.82 | HIF1A (0.50) | HIF1AEPAS1SERPINE1NPC1ALDH1A1 | |
| SCHEMBL22453002 | 0.81 | DHODH (0.50) | HIF1AEPAS1SERPINE1NPC1ALDH1A1 | |
| SCHEMBL22453117 | 0.81 | CNR2 (0.53) | HIF1AEPAS1NPC1ALDH1A1HTT | |
| SCHEMBL22452811 | 0.81 | HIF1A (0.52) | HIF1AEPAS1SERPINE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |