Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453756 | 0.91 | CNR2 (0.49) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22453069 | 0.88 | RAB9A (0.47) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22453641 | 0.87 | DHODH (0.55) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22452811 | 0.86 | HIF1A (0.52) | MEN1KMT2AALDH1A1HIF1AEPAS1 | |
| SCHEMBL22453346 | 0.85 | GRM4 (0.40) | MEN1KMT2ARAB9AHIF1AEPAS1 | |
| SCHEMBL22452743 | 0.84 | PDE10A (0.45) | RAB9ANPC1HTTALDH1A1NPSR1 | |
| SCHEMBL22453640 | 0.84 | DHODH (0.57) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22452804 | 0.82 | SERPINE1 (0.57) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22453002 | 0.81 | DHODH (0.50) | DHODHMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22453313 | 0.81 | DHODH (0.48) | DHODHMEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |