Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARG | Q86W56 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PNLIP | P16233 | 8/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453205 | 0.90 | MAPT (0.46) | HIF1AEPAS1MAPTPNLIPEPHX2 | |
| SCHEMBL22452486 | 0.88 | HIF1A (0.50) | HIF1AEPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL22453074 | 0.87 | PARP1 (0.41) | HIF1AEPAS1PARP1PARGMEN1 | |
| SCHEMBL22453075 | 0.86 | DHODH (0.49) | HIF1AEPAS1PARP1PARGMEN1 | |
| SCHEMBL31555348 | 0.82 | HIF1A (0.60) | HIF1AEPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL22452498 | 0.82 | HIF1A (0.60) | HIF1AEPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL22452789 | 0.82 | SERPINE1 (0.61) | HIF1AEPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL22453058 | 0.81 | HIF1A (0.47) | HIF1AEPAS1MEN1KMT2AALDH1A1 | |
| SCHEMBL22452478 | 0.81 | HIF1A (0.40) | HIF1AEPAS1PARP1PARGPNLIP | |
| SCHEMBL22452819 | 0.80 | HIF1A (0.41) | HIF1AEPAS1PARP1PARGKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |