Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
| ▸ | CASP2 | P42575 | 1/20 | 0.30 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452697 | 0.86 | SERPINE1 (0.41) | LMNAMAPTGAAHTTNPSR1 | |
| SCHEMBL22452574 | 0.84 | CNR2 (0.41) | LMNANPC1SMN1; SMN2HIF1ASERPINE1 | |
| SCHEMBL22452747 | 0.78 | SERPINE1 (0.41) | LMNAMAPTGAAHTTNPSR1 | |
| SCHEMBL22452529 | 0.76 | DHODH (0.41) | LMNAMAPTHTTNPSR1NPC1 | |
| SCHEMBL22452579 | 0.76 | CNR2 (0.40) | LMNAMAPTGAAHTTNPSR1 | |
| SCHEMBL22452888 | 0.76 | EPHX2 (0.36) | LMNAMAPTGAANPC1SMN1; SMN2 | |
| SCHEMBL22453118 | 0.75 | CA12 (0.42) | LMNAMAPTGAAHTTNPSR1 | |
| SCHEMBL22453106 | 0.74 | EPHX2 (0.39) | LMNAGAAHTTNPC1HIF1A | |
| SCHEMBL22453269 | 0.74 | SERPINE1 (0.42) | LMNANPC1SMN1; SMN2HIF1AEPHX2 | |
| SCHEMBL22452964 | 0.72 | NPC1 (0.43) | LMNAMAPTGAANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |