Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PNLIP | P16233 | 7/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.42 |
| ▸ | MDH1 | P40925 | 2/20 | 0.41 |
| ▸ | MDH2 | P40926 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452811 | 0.90 | HIF1A (0.52) | MAPTPNLIPHIF1AEPAS1EPHX2 | |
| SCHEMBL22453525 | 0.89 | MAPT (0.50) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22452507 | 0.88 | MAPT (0.53) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22453756 | 0.87 | CNR2 (0.49) | MAPTPNLIPHIF1AEPAS1MDH1 | |
| SCHEMBL22452503 | 0.84 | MAPT (0.58) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22452790 | 0.83 | SERPINE1 (0.51) | MAPTALOX15HIF1AEPAS1 | |
| SCHEMBL22453789 | 0.83 | KMT2A (0.41) | PNLIPHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL22453774 | 0.82 | LMNA (0.47) | MAPTALOX15CYP3A4 | |
| SCHEMBL22453680 | 0.81 | SERPINE1 (0.53) | MAPTALOX15HIF1A | |
| SCHEMBL22452501 | 0.81 | MAPT (0.55) | MAPTALOX15HIF1AEPAS1MDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |