Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18542859 | 0.85 | NOTUM (0.37) | MEN1KMT2ANOTUMOPRM1MAPT | |
| SCHEMBL18542893 | 0.85 | MEN1 (0.36) | MEN1KMT2ANOTUMOPRM1ALDH1A1 | |
| SCHEMBL9416784 | 0.84 | LMNA (0.40) | MEN1KMT2AOPRM1OPRD1MAPT | |
| SCHEMBL2090069 | 0.73 | MEN1 (0.47) | MEN1KMT2ATDP1NOTUMMAPT | |
| SCHEMBL30936910 | 0.73 | ALDH1A1 (0.37) | MEN1KMT2ATDP1OPRM1OPRD1 | |
| SCHEMBL24680602 | 0.70 | NPSR1 (0.42) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL13580923 | 0.70 | MEN1 (0.45) | MEN1KMT2ATDP1NOTUMMAPT | |
| SCHEMBL9416717 | 0.70 | MEN1 (0.48) | MEN1KMT2AOPRM1MAPTLMNA | |
| SCHEMBL12550520 | 0.68 | ALDH1A1 (0.49) | MEN1KMT2ATDP1MAPTLMNA | |
| SCHEMBL23704985 | 0.68 | HPGD (0.45) | MEN1KMT2ATDP1NOTUMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |