Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PNLIP | P16233 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452868 | 0.94 | MEN1 (0.53) | MAPK10MAPK8KMT2AMEN1LMNA | |
| SCHEMBL22452912 | 0.90 | KMT2A (0.52) | MAPK10MAPK8KMT2AMEN1LMNA | |
| SCHEMBL22453389 | 0.87 | MAPK10 (0.45) | MAPK10MAPK8KMT2AMEN1LMNA | |
| SCHEMBL22452870 | 0.83 | DHODH (0.54) | MAPK10MAPK8KMT2AMEN1LMNA | |
| SCHEMBL22452737 | 0.80 | MEN1 (0.53) | MAPK10MAPK8KMT2AMEN1LMNA | |
| SCHEMBL22453595 | 0.77 | KMT2A (0.51) | KMT2AMEN1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL22452913 | 0.76 | LIPE (0.44) | KMT2AMEN1LMNAPOLBMAPT | |
| SCHEMBL19808908 | 0.75 | ACACB (0.49) | MAPK10MAPK8KMT2ALMNAKDM4E | |
| SCHEMBL22208638 | 0.74 | MAPK10 (0.46) | MAPK10MAPK8LMNAMAPTTDP1 | |
| SCHEMBL31697202 | 0.74 | MAPK10 (0.46) | MAPK10MAPK8LMNAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |