Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452870 | 0.93 | DHODH (0.54) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL22452909 | 0.90 | MAPK10 (0.51) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL22453595 | 0.88 | KMT2A (0.51) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL22453389 | 0.86 | MAPK10 (0.45) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL22452868 | 0.84 | MEN1 (0.53) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL22452471 | 0.80 | MEN1 (0.63) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL22452737 | 0.79 | MEN1 (0.53) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL19808846 | 0.78 | LMNA (0.60) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL11212618 | 0.77 | TDP1 (0.54) | KMT2AMEN1MAPTTDP1ATM | |
| SCHEMBL22453592 | 0.77 | MRGPRX4 (0.53) | KMT2AMEN1MAPK10MAPK8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |