Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17744810 | 0.84 | NPC1 (0.58) | — | |
| SCHEMBL15214804 | 0.82 | HDAC8 (0.69) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL12323478 | 0.82 | HDAC3 (0.55) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL16022191 | 0.81 | HDAC8 (0.76) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL11468423 | 0.80 | POLB (0.66) | HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL4658995 | 0.79 | RAB9A (0.55) | — | |
| SCHEMBL15214807 | 0.79 | HDAC8 (0.64) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL14113415 | 0.78 | HDAC3 (0.67) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL16705207 | 0.78 | HDAC8 (0.71) | HDAC3HDAC11HDAC8HDAC6DEGS1 | |
| SCHEMBL15214829 | 0.78 | HDAC8 (0.71) | HDAC3HDAC11HDAC8HDAC6DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |