Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272758 | 0.85 | KMT2A (0.60) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL6332639 | 0.85 | MEN1 (0.60) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL7440301 | 0.85 | MEN1 (0.60) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL22453338 | 0.85 | RAB9A (0.59) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL7271426 | 0.84 | MEN1 (0.58) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL7281318 | 0.84 | MEN1 (0.81) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL2410062 | 0.84 | LMNA (0.72) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL28949487 | 0.84 | LMNA (0.71) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL29898238 | 0.84 | LMNA (0.71) | MEN1KMT2APKMHTTMAPK1 | |
| SCHEMBL7281512 | 0.83 | DHODH (0.71) | MEN1KMT2APKMHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |