Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | FADS1 | O60427 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | PLAU | P00749 | 3/20 | 0.38 |
| ▸ | PLAT | P00750 | 3/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453892 | 0.89 | LRRK2 (0.55) | LRRK2HDAC1FADS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22453421 | 0.77 | LRRK2 (0.43) | LRRK2HDAC1FADS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22453429 | 0.77 | LRRK2 (0.42) | LRRK2PRKCIHDAC1KDM4ERAB9A | |
| SCHEMBL22452996 | 0.77 | LRRK2 (0.50) | LRRK2HDAC1F2PLAUPLAT | |
| SCHEMBL22889931 | 0.76 | LRRK2 (0.59) | LRRK2ALDH1A1SMN1; SMN2F2F10 | |
| SCHEMBL22453342 | 0.74 | LRRK2 (0.46) | LRRK2HDAC1FADS1BRAFHDAC8 | |
| SCHEMBL22452978 | 0.74 | LRRK2 (0.51) | LRRK2FADS1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL22454024 | 0.73 | KMT2A (0.48) | HDAC1ALDH1A1SMN1; SMN2F2F10 | |
| SCHEMBL22452969 | 0.72 | LRRK2 (0.48) | LRRK2HDAC1FADS1SMN1; SMN2RAB9A | |
| SCHEMBL22065324 | 0.70 | FADS1 (0.54) | HDAC1FADS1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |