Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PNLIP | P16233 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452448 | 0.92 | MEN1 (0.63) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL22453595 | 0.83 | KMT2A (0.51) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL22453594 | 0.78 | MEN1 (0.47) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL10685122 | 0.76 | TDP1 (0.74) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL22452471 | 0.75 | MEN1 (0.63) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL11158177 | 0.73 | KMT2A (0.67) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL22452909 | 0.73 | MAPK10 (0.51) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL10685864 | 0.72 | MRGPRX4 (0.51) | MAPTMEN1LMNAKMT2APOLB | |
| SCHEMBL22453592 | 0.72 | MRGPRX4 (0.53) | MAPTMEN1KMT2APNLIPTDP1 | |
| SCHEMBL22452605 | 0.71 | KMT2A (0.67) | MAPTMEN1LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |