Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453545 | 0.88 | HPGD (0.52) | HIF1AHPGDMAPK1RECQLSLC2A1 | |
| SCHEMBL22452974 | 0.86 | HIF1A (0.53) | HIF1ANPC1EPAS1 | |
| SCHEMBL22453416 | 0.82 | HIF1A (0.42) | HIF1AHPGDMAPK1RECQLSLC2A1 | |
| SCHEMBL22452572 | 0.80 | MAPT (0.45) | HIF1AHPGDMAPK1RECQLMEN1 | |
| SCHEMBL22453411 | 0.80 | SYK (0.39) | HIF1AHPGDMAPK1RECQLRAB9A | |
| SCHEMBL22453142 | 0.80 | EPHX2 (0.40) | HIF1AHPGDMAPK1RECQLNPC1 | |
| SCHEMBL22453603 | 0.78 | HIF1A (0.43) | HIF1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL22453555 | 0.77 | HIF1A (0.44) | HIF1ANPC1ALDH1A1EPAS1MAPT | |
| SCHEMBL22453836 | 0.77 | HIF1A (0.45) | HIF1AJAK2TYK2EPAS1 | |
| SCHEMBL22453106 | 0.76 | EPHX2 (0.39) | HIF1AMAPK1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |