Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453409 | 0.88 | HIF1A (0.49) | HPGDMAPK1RECQLHIF1ASMN1; SMN2 | |
| SCHEMBL22452572 | 0.86 | MAPT (0.45) | HPGDMAPK1RECQLHIF1AGAA | |
| SCHEMBL22453416 | 0.84 | HIF1A (0.42) | HPGDMAPK1RECQLHIF1ASMN1; SMN2 | |
| SCHEMBL22453415 | 0.83 | SERPINE1 (0.53) | HPGDMAPK1RECQLHIF1AGAA | |
| SCHEMBL22453411 | 0.83 | SYK (0.39) | HPGDMAPK1RECQLHIF1ASMN1; SMN2 | |
| SCHEMBL22452573 | 0.83 | EPHX2 (0.57) | HIF1ATHRBEPHX2MAPT | |
| SCHEMBL22452964 | 0.81 | NPC1 (0.43) | GAASMN1; SMN2MEN1KMT2AEPHX2 | |
| SCHEMBL22453505 | 0.80 | HIF1A (0.55) | HPGDHIF1ANPSR1RAB9AMEN1 | |
| SCHEMBL22453525 | 0.79 | MAPT (0.50) | HIF1ASMN1; SMN2MEN1KMT2AEPHX2 | |
| SCHEMBL22452681 | 0.77 | ALDH1A1 (0.57) | HPGDGAASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |