Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453611 | 0.89 | P2RX7 (0.43) | EPHX2SERPINE1MAPK1NPC1PTK2 | |
| SCHEMBL22452486 | 0.88 | HIF1A (0.50) | EPHX2SERPINE1NPC1LMNAMAPT | |
| SCHEMBL22453525 | 0.88 | MAPT (0.50) | EPHX2SERPINE1NPC1LMNAMAPT | |
| SCHEMBL22452762 | 0.87 | SIRT2 (0.46) | EPHX2SERPINE1NPC1MAPK10MAPK9 | |
| SCHEMBL22453612 | 0.87 | P2RX7 (0.43) | EPHX2SERPINE1NPC1MAPK10MAPK9 | |
| SCHEMBL31555349 | 0.82 | SERPINE1 (0.51) | EPHX2SERPINE1NPC1LMNAMAPT | |
| SCHEMBL22453520 | 0.82 | SERPINE1 (0.51) | EPHX2SERPINE1NPC1LMNAMAPT | |
| SCHEMBL22452789 | 0.82 | SERPINE1 (0.61) | EPHX2SERPINE1NPC1LMNAMAPT | |
| SCHEMBL22452715 | 0.82 | SERPINE1 (0.64) | EPHX2SERPINE1NPC1LMNAMAPT | |
| SCHEMBL22452790 | 0.82 | SERPINE1 (0.51) | POLBSERPINE1NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |