Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | MDH1 | P40925 | 1/20 | 0.41 |
| ▸ | MDH2 | P40926 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452981 | 0.91 | SIRT2 (0.52) | SIRT2PGREPHX2MEN1POLB | |
| SCHEMBL22453480 | 0.86 | MAPT (0.52) | SIRT2MAPTALOX15PGREPHX2 | |
| SCHEMBL22453564 | 0.83 | MAPT (0.46) | SIRT2MAPTALOX15PGRHIF1A | |
| SCHEMBL22452748 | 0.82 | SIRT2 (0.49) | SIRT2PGRHIF1AEPAS1EPHX2 | |
| SCHEMBL22453226 | 0.81 | HIF1A (0.53) | MAPTHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL22453695 | 0.79 | SIRT2 (0.50) | SIRT2MAPTALOX15RAB9APDE5A | |
| SCHEMBL22453221 | 0.78 | HIF1A (0.51) | SIRT2MAPTALOX15PGRHIF1A | |
| SCHEMBL22452577 | 0.78 | HIF1A (0.51) | SIRT2MAPTALOX15PGRHIF1A | |
| SCHEMBL22452690 | 0.78 | SIRT2 (0.57) | SIRT2PGRHIF1AEPAS1MDH1 | |
| SCHEMBL22452501 | 0.76 | MAPT (0.55) | SIRT2MAPTALOX15HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |