Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452805 | 0.89 | FABP4 (0.47) | MAPTALOX15EPHX2ALDH1A1HPGD | |
| SCHEMBL22453566 | 0.86 | SIRT2 (0.48) | MAPTALOX15SIRT2EPHX2KDM4E | |
| SCHEMBL22452503 | 0.85 | MAPT (0.58) | MAPTALOX15SIRT2EPHX2KDM4E | |
| SCHEMBL22453477 | 0.82 | LMNA (0.42) | MAPTALOX15KDM4EALDH1A1HPGD | |
| SCHEMBL22453564 | 0.82 | MAPT (0.46) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL22452748 | 0.81 | SIRT2 (0.49) | SIRT2EPHX2POLBKMT2APGR | |
| SCHEMBL22452501 | 0.80 | MAPT (0.55) | MAPTALOX15SIRT2EPHX2ALDH1A1 | |
| SCHEMBL22452507 | 0.79 | MAPT (0.53) | MAPTALOX15SIRT2EPHX2KDM4E | |
| SCHEMBL22452652 | 0.79 | EPHX2 (0.61) | MAPTALOX15SIRT2EPHX2KDM4E | |
| SCHEMBL22452848 | 0.78 | MAPT (0.49) | MAPTALOX15SIRT2EPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |