Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453229 | 0.91 | SIRT2 (0.50) | SIRT2PGREPHX2MEN1KMT2A | |
| SCHEMBL22452805 | 0.91 | FABP4 (0.47) | PGREPHX2MEN1KMT2AHIF1A | |
| SCHEMBL22452981 | 0.91 | SIRT2 (0.52) | SIRT2PGREPHX2MEN1KMT2A | |
| SCHEMBL22452527 | 0.86 | SERPINE1 (0.57) | SIRT2PGREPHX2MEN1KMT2A | |
| SCHEMBL22453497 | 0.86 | SERPINE1 (0.57) | SIRT2PGREPHX2MEN1KMT2A | |
| SCHEMBL22453566 | 0.82 | SIRT2 (0.48) | SIRT2PGREPHX2MEN1KMT2A | |
| SCHEMBL22453564 | 0.82 | MAPT (0.46) | SIRT2PGRMEN1KMT2AHIF1A | |
| SCHEMBL22453480 | 0.81 | MAPT (0.52) | SIRT2PGREPHX2MEN1KMT2A | |
| SCHEMBL22453295 | 0.80 | PGR (0.44) | PGREPHX2MEN1KMT2APOLB | |
| SCHEMBL22453626 | 0.79 | SERPINE1 (0.65) | SIRT2PGREPHX2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |