Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23969872 | 0.87 | NPC1 (0.39) | NPC1 | |
| SCHEMBL22452968 | 0.83 | NPC1 (0.52) | NPC1 | |
| SCHEMBL23969868 | 0.71 | LMNA (0.41) | NPC1 | |
| SCHEMBL10012654 | 0.68 | NPC1 (0.57) | NPC1 | |
| SCHEMBL25720525 | 0.65 | MEN1 (0.39) | NPC1 | |
| SCHEMBL22815627 | 0.65 | MAPT (0.40) | NPC1 | |
| SCHEMBL12882560 | 0.64 | LMNA (0.47) | — | |
| SCHEMBL26017002 | 0.62 | MEN1 (0.36) | NPC1 | |
| SCHEMBL22453737 | 0.59 | EPHX2 (0.45) | NPC1 | |
| SCHEMBL11457438 | 0.59 | EPHX2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |