Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453675 | 0.87 | NPC1 (0.32) | NPC1 | |
| SCHEMBL23969868 | 0.81 | LMNA (0.41) | NPC1EPHX2LMNAMAPTALDH1A1 | |
| SCHEMBL10012654 | 0.78 | NPC1 (0.57) | NPC1EPHX2LMNAMAPTALDH1A1 | |
| SCHEMBL25720525 | 0.74 | MEN1 (0.39) | NPC1EPHX2LMNAMAPTALDH1A1 | |
| SCHEMBL22815627 | 0.74 | MAPT (0.40) | NPC1EPHX2LMNAMAPTALDH1A1 | |
| SCHEMBL26017002 | 0.71 | MEN1 (0.36) | NPC1LMNAALDH1A1 | |
| SCHEMBL22452968 | 0.68 | NPC1 (0.52) | NPC1EPHX2LMNAMAPTALDH1A1 | |
| SCHEMBL22453706 | 0.68 | MAPT (0.52) | EPHX2MAPTALDH1A1 | |
| SCHEMBL22453737 | 0.68 | EPHX2 (0.45) | NPC1EPHX2LMNAMAPTALDH1A1 | |
| SCHEMBL11457438 | 0.68 | EPHX2 (0.38) | EPHX2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353156-B1 | TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-11-03 | — | — | EP | disclosed |