Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28014562 | 0.83 | NPC1 (0.58) | NPC1PGRSMN1; SMN2MAPTNAMPT | |
| SCHEMBL28205308 | 0.81 | NPC1 (0.82) | NPC1PGREPHX2SMN1; SMN2MAPT | |
| SCHEMBL22453610 | 0.80 | EPHX2 (0.50) | NPC1PGREPHX2MAPTLMNA | |
| SCHEMBL22445036 | 0.80 | NPC1 (1.00) | NPC1PGREPHX2SMN1; SMN2MAPT | |
| SCHEMBL22453123 | 0.79 | EPHX2 (0.43) | NPC1PGREPHX2MAPTALDH1A1 | |
| SCHEMBL22452630 | 0.79 | LMNA (0.45) | NPC1PGREPHX2POLBLMNA | |
| Memantine SCHEMBL8154506 | 0.77 | MAPT (0.53) | NPC1PGREPHX2SMN1; SMN2MAPT | |
| SCHEMBL5006770 | 0.77 | EPHX2 (0.46) | NPC1EPHX2POLBLMNAHTT | |
| SCHEMBL22453506 | 0.75 | LMNA (0.47) | NPC1PGREPHX2MAPTLMNA | |
| SCHEMBL12302270 | 0.75 | NPC1 (0.59) | NPC1PGRSMN1; SMN2MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |