Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452629 | 0.87 | NPC1 (0.59) | LMNAMAPK1KMT2ANPC1PGR | |
| SCHEMBL22453463 | 0.86 | CRHBP (0.39) | KMT2AALDH1A1TDP1EPHX2 | |
| SCHEMBL22453123 | 0.84 | EPHX2 (0.43) | NPC1PGRALDH1A1EPHX2 | |
| SCHEMBL22452710 | 0.83 | MEN1 (0.44) | LMNAKMT2AALDH1A1POLBTDP1 | |
| SCHEMBL22453477 | 0.82 | LMNA (0.42) | LMNAMAPK1KMT2AALDH1A1 | |
| SCHEMBL22452713 | 0.81 | DHODH (0.43) | LMNAMAPK1KMT2ANPC1ALDH1A1 | |
| SCHEMBL22453686 | 0.79 | NPC1 (0.67) | LMNAKMT2ANPC1PGRALDH1A1 | |
| SCHEMBL11887610 | 0.74 | MAPK1 (0.70) | LMNAMAPK1KMT2AALDH1A1BDKRB1 | |
| SCHEMBL22452967 | 0.72 | NPC1 (0.75) | MAPK1KMT2ANPC1PGRALDH1A1 | |
| SCHEMBL22453465 | 0.71 | ALDH1A1 (0.50) | LMNAPGRALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |