Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453093 | 0.81 | CNR2 (0.57) | MAPTALOX15SIRT2HPGDTSHR | |
| SCHEMBL13224505 | 0.74 | MAPT (0.89) | MAPTALOX15SIRT2HPGDMAPK10 | |
| SCHEMBL22453221 | 0.73 | HIF1A (0.51) | MAPTALOX15SIRT2HPGDMAPK10 | |
| SCHEMBL22452577 | 0.73 | HIF1A (0.51) | MAPTALOX15SIRT2HPGDMAPK10 | |
| SCHEMBL22452503 | 0.72 | MAPT (0.58) | MAPTALOX15SIRT2TSHRKDM4E | |
| SCHEMBL22453751 | 0.72 | HPGD (0.55) | MAPTHPGDMAPK10CYP1A2CYP2D6 | |
| SCHEMBL31168050 | 0.71 | MAPT (0.79) | MAPTALOX15SIRT2HPGDMAPK10 | |
| SCHEMBL22445145 | 0.71 | MAPT (0.79) | MAPTALOX15SIRT2HPGDMAPK10 | |
| SCHEMBL12605599 | 0.70 | MAPT (0.76) | MAPTALOX15SIRT2HPGDMAPK10 | |
| SCHEMBL12109319 | 0.70 | MAPT (0.81) | MAPTALOX15SIRT2HPGDMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |