Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.79 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.67 |
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31168050 | 1.00 | MAPT (0.79) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL13224505 | 0.90 | MAPT (0.89) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL31914 | 0.89 | MAPT (1.00) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL28649151 | 0.86 | MAPT (0.81) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL12109319 | 0.85 | MAPT (0.81) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL29514750 | 0.85 | FABP4 (0.73) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL11325566 | 0.85 | FABP4 (0.73) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL28658698 | 0.84 | MAPT (0.78) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL22453219 | 0.84 | MAPT (0.72) | MAPTALOX15SIRT2AURKAPOLB | |
| SCHEMBL22452889 | 0.83 | MAPT (0.76) | MAPTALOX15SIRT2AURKAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3937943-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | The General Hospital Corporation (US) | 2022-01-19 | — | — | EP | disclosed |
| CN-113811300-A | Novel small molecule inhibitors of TEAD transcription factor | 总医院公司 | 2021-12-17 | — | — | CN | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |