Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.57 |
| ▸ | FAAH | O00519 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452816 | 0.87 | FAAH (0.64) | CNR2FAAHMAPTEPHX2PKM | |
| SCHEMBL22453323 | 0.86 | FAAH (0.63) | CNR2FAAHMAPTEPHX2PKM | |
| SCHEMBL22453221 | 0.83 | HIF1A (0.51) | MAPTALOX15EPHX2HPGDTSHR | |
| SCHEMBL22452577 | 0.83 | HIF1A (0.51) | MAPTALOX15EPHX2HPGDTSHR | |
| SCHEMBL22453769 | 0.81 | MAPT (0.50) | MAPTALOX15EPHX2KDM4EALDH1A1 | |
| SCHEMBL22452503 | 0.80 | MAPT (0.58) | CNR2MAPTALOX15EPHX2KDM4E | |
| SCHEMBL19736415 | 0.80 | CNR2 (0.76) | CNR2FAAHMAPTEPHX2PKM | |
| SCHEMBL22453751 | 0.79 | HPGD (0.55) | MAPTEPHX2KDM4EALDH1A1HPGD | |
| SCHEMBL13224505 | 0.77 | MAPT (0.89) | MAPTALOX15KDM4EALDH1A1HPGD | |
| SCHEMBL22452652 | 0.76 | EPHX2 (0.61) | CNR2MAPTALOX15EPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |