Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FADS1 | O60427 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453946 | 0.84 | LRRK2 (0.35) | LRRK2LCKSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL22453185 | 0.77 | LRRK2 (0.46) | LRRK2SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL22453793 | 0.75 | LRRK2 (0.46) | LRRK2SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL22452978 | 0.74 | LRRK2 (0.51) | LRRK2SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL22453874 | 0.74 | LRRK2 (0.43) | LRRK2 | |
| SCHEMBL22453892 | 0.71 | LRRK2 (0.55) | LRRK2SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL22453216 | 0.68 | LRRK2 (0.47) | LRRK2LCKKDRSMN1; SMN2RAB9A | |
| SCHEMBL22445872 | 0.68 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNATP53MAPTALDH1A1 | |
| SCHEMBL22452996 | 0.68 | LRRK2 (0.50) | LRRK2RAB9ANPC1LMNAMAPT | |
| SCHEMBL22453384 | 0.67 | LRRK2 (0.50) | LRRK2SMN1; SMN2RAB9AALDH1A1FADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |