Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | CA12 | O43570 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | CA7 | P43166 | 2/20 | 0.59 |
| ▸ | CA9 | Q16790 | 2/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250288 | 0.93 | RAB9A (0.57) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL11900945 | 0.93 | POLB (0.58) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL11901124 | 0.83 | CA12 (0.53) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL3936871 | 0.83 | RAB9A (0.51) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL87450 | 0.82 | CA1 (0.83) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL11901153 | 0.82 | CA12 (0.51) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL11769771 | 0.81 | CA1 (0.73) | RAB9ACA12CA1CA2CA7 | |
| Cyclohexane SCHEMBL2917907 | 0.81 | CA1 (0.73) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL7746905 | 0.80 | CA1 (0.79) | RAB9ACA12CA1CA2CA7 | |
| SCHEMBL21440358 | 0.80 | CA1 (0.79) | RAB9ACA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2686325-B1 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2016-12-14 | — | — | EP | disclosed |
| CN-103517910-B | Morpholine-spirocyclic piperidine amides as modulators of ion channels | 沃泰克斯药物股份有限公司 | 2016-12-14 | — | — | CN | disclosed |
| US-9181273-B2 | Morpholine-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-10 | — | — | US | disclosed |
| US-20150025073-A1 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC | 2015-01-22 | — | — | US | disclosed |
| US-8828996-B2 | Morpholine-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-09 | — | — | US | disclosed |
| US-8729104-B2 | Diphenyl substituted alkanes as flap inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729104-B2 | Diphenyl substituted alkanes as flap inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729104-B2 | Diphenyl substituted alkanes as flap inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-20 | — | — | US | disclosed |
| EP-2686325-A1 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2014-01-22 | — | — | EP | disclosed |
| CN-103517910-A | Morpholine-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA | 2014-01-15 | — | — | CN | disclosed |
| WO-2006044602-A2 | DIPHENYL SUBSTITUTED ALKANES AS FLAP INHIIBITORS | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | disclosed |
| WO-2005082367-A1 | KINASE INHIBITORS | DEVGEN NV (BE) | 2005-09-09 | — | — | WO | disclosed |
| EP-1016420-B1 | Synergistic detergent and disinfectant combinations for decontaminating biofilm-coated surfaces | UNIV MONTREAL (CA) | 2003-05-07 | — | — | EP | disclosed |
| EP-0800408-B1 | SYNERGISTIC DETERGENT AND DISINFECTANT COMBINATIONS FOR DECONTAMINATING BIOFILM-COATED SURFACES | UNIV MONTREAL (CA) | 2001-12-12 | — | — | EP | disclosed |
| EP-1135337-A2 | WATER SANITIZING SYSTEM | Hygenitek Inc. (CA) | 2001-09-26 | — | — | EP | disclosed |
| EP-1016420-A1 | Synergistic detergent and disinfectant combinations for decontaminating biofilm-coated surfaces | UNIVERSITE DE MONTREAL (CA) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999048817-A2 | WATER SANITIZING SYSTEM | HYGENITEK INC. (CA) | 1999-09-30 | — | — | WO | disclosed |
| US-5942480-A | AQUEOUS MIXTURE CONTAINING MANDELIC ACID, LACTIC ACID, SODIUM DODECYL SULFATE, EDTA, HYDROGEN PEROXIDE, CETYLPYRIDINIUM CHLORIDE AND PERACETIC ACID | UNIVERSITE DE MONTREAL (CA) | 1999-08-24 | — | — | US | disclosed |
| US-5759970-A | CONTAINING HYDROGEN PEROXIDE, EDTA AND SODIUM DODECYL SULFATE; WATER SUPPLY LINES TO DENTAL INSTRUMENTS | UNIVERSITE DE MONTREAL (CA) | 1998-06-02 | — | — | US | disclosed |
| US-5731275-A | LACTIC AND MANDELIC ACIDS, SODIUM DODECYL SULFATE; DENTAL EQUIPMENT | UNIVERSITE DE MONTREAL (CA) | 1998-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025073-A1 | MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | KCNJ2, TRPM5, KCNQ1 | RAB9A 1540/4885CA12 4475/4885CA1 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.