Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 5/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804988 | 0.81 | AHR (0.50) | AHRCYP1B1NPC1RAB9ANOTUM | |
| SCHEMBL436469 | 0.81 | NOTUM (0.38) | AHRNPC1RAB9ANOTUMPTGS2 | |
| SCHEMBL28357214 | 0.80 | ALDH1A1 (0.35) | NPC1RAB9AMAPTMEN1GAA | |
| SCHEMBL5797082 | 0.78 | MAOB (0.35) | NPC1RAB9AKDM4EMAPTPTGS2 | |
| SCHEMBL17047386 | 0.78 | HSD17B10 (0.48) | AHRCYP1B1NPC1RAB9ANOTUM | |
| SCHEMBL10941967 | 0.78 | AHR (0.46) | AHRCYP1B1NPC1RAB9ANOTUM | |
| SCHEMBL8529054 | 0.77 | AHR (0.42) | AHRCYP1B1NOTUMHTR2ASLC6A4 | |
| SCHEMBL9521923 | 0.77 | NOTUM (0.35) | NOTUMPTGS2KMO | |
| SCHEMBL9649089 | 0.77 | TSHR (0.32) | — | |
| SCHEMBL7507597 | 0.76 | GABRP (0.42) | NPC1RAB9ANOTUMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179563-A1 | PROCESS FOR THE MANUFACTURE OF IMINIUM COMPOUNDS AND THEIR APPLICATION IN THE MANUFACTURE OF PYRAZOLE DERIVATIVES | SOLVAY SA (BE) | 2021-06-17 | — | — | US | disclosed |
| US-20210171468-A1 | PROCESS FOR THE MANUFACTURE OF PYRAZOLE CARBOXYLIC DERIVATIVES AND PRECURSORS THEREOF | SOLVAY SA (BE) | 2021-06-10 | — | — | US | disclosed |
| US-20200305431-A1 | PROCESS FOR THE MANUFACTURE OF PYRAZOLE COMPOUNDS | SOLVAY SA (BE) | 2020-10-01 | — | — | US | disclosed |
| CN-111587242-A | Process for producing pyrazole compound | 索尔维公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-111587241-A | Method for producing iminium compound and use thereof for producing pyrazole derivative | 索尔维公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-111566093-A | Method for producing pyrazolecarboxylic acid derivative and precursor thereof | 索尔维公司 | 2020-08-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200305431-A1 | PROCESS FOR THE MANUFACTURE OF PYRAZOLE COMPOUNDS | CYP3A4, CYP3A43, CYP2E1 | AHR 78/4885CYP1B1 9/4885NPC1 2185/4885 |
| US-20210171468-A1 | PROCESS FOR THE MANUFACTURE OF PYRAZOLE CARBOXYLIC DERIVATIVES AND PRECURSORS THEREOF | CYP3A4, CYP3A43, CYP3A5 | AHR 144/4885CYP1B1 15/4885NPC1 3582/4885 |
| US-20210179563-A1 | PROCESS FOR THE MANUFACTURE OF IMINIUM COMPOUNDS AND THEIR APPLICATION IN THE MANUFACTURE OF PYRAZOLE DERIVATIVES | CYP3A5, CYP3A4, CYP3A43 | AHR 481/4885CYP1B1 20/4885NPC1 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.