Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797082 | 0.85 | MAOB (0.35) | NPC1RAB9ACYP1A2PTGS2ALOX5 | |
| SCHEMBL9649089 | 0.84 | TSHR (0.32) | TSHRGRM5 | |
| SCHEMBL436851 | 0.81 | AHR (0.38) | NOTUMNPC1TP53TSHRRAB9A | |
| SCHEMBL22463151 | 0.81 | AHR (0.46) | NOTUMNPC1TP53RAB9AAHR | |
| SCHEMBL1116582 | 0.80 | GABRP (0.38) | NOTUMNPC1TP53TSHRRAB9A | |
| SCHEMBL9128405 | 0.80 | TAAR1 (0.47) | NPC1TP53RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL3905765 | 0.80 | AHR (0.33) | AHRCYP2A6GABRPGABRDGABRA1 | |
| SCHEMBL5796805 | 0.80 | ESR2 (0.47) | ALOX5 | |
| SCHEMBL8665602 | 0.80 | — | — | |
| SCHEMBL9648734 | 0.80 | ACHE (0.41) | NPC1RAB9ASMN1; SMN2PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017035114-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | claimed |
| US-7504412-B2 | Imidazopyridine derivatives | BANYU PHARMACEUTICALS, CO., LTD. (JP) | 2009-03-17 | — | — | US | claimed |
| US-5973190-A | Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds | AMERICAN CYANAMID COMPANY (US) | 1999-10-26 | — | — | US | claimed |
| EP-2780326-A1 | METHOD FOR INHIBITION OF DEUBIQUITINATING ACTIVITY | Vivolux Ab (SE) | 2014-09-24 | — | — | EP | disclosed |
| EP-2595984-A1 | MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2595985-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2013058691-A1 | METHOD FOR INHIBITION OF DEUBIQUITINATING ACTIVITY | VIVOLUX AB (SE) | 2013-04-25 | — | — | WO | disclosed |
| WO-2012010568-A1 | MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012010567-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| US-8071810-B2 | 3-(3-Amino-2,6-diisopropyl-phenyl)-1-(4-isopropyl-phenyl)-1-(4-methoxy-benzyl)-urea; autoimmune disorders; inflammation | JERINI AG (DE) | 2011-12-06 | — | — | US | disclosed |
| US-7491727-B2 | Good selectivity, high affinity, metabolically stable 5-HT receptor modulators with good bioavailability, CNS penetration, and good pharmacokinetic; antiserotonine agents; central nervous system disorders; anxiolytic agents; attention deficit disorders; strokes; headaches | EPIX DELAWARE, INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-5156669-A | Fungicides and plant growth regulators | BASF AKTIENGESELLSCHAFT (DE) | 1992-10-20 | — | — | US | disclosed |
| US-5120848-A | Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | GLAXO GROUP LIMITED (GB) | 1992-06-09 | — | — | US | disclosed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |
| US-5004494-A | Fungicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-02 | — | — | US | disclosed |
| US-4946493-A | FUNGICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-07 | — | — | US | disclosed |
| US-4845250-A | FUNGICIDES, PLANT GROWTH REGULATORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-07-04 | — | — | US | disclosed |
| US-4792554-A | Pyridine compounds, pharaceutical compositions, their use in allergy therapy | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-12-20 | — | — | US | disclosed |
| EP-0224159-A1 | Pyridine compounds, substituted by basic groups, process for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-06-03 | — | — | EP | disclosed |
| US-4507140-A | GALLIUM ARSENIDE DOPED WITH GERMANIUM AND TELLURIUM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-03-26 | — | — | US | disclosed |