Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.60 |
| ▸ | CA1 | P00915 | 4/20 | 0.60 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.43 |
| ▸ | FPGS | Q05932 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246061 | 0.87 | CA2 (0.69) | CA2CA1MMP2MMP9C3AR1 | |
| SCHEMBL2245325 | 0.87 | CA2 (0.69) | CA2CA1MMP2MMP9C3AR1 | |
| SCHEMBL5508045 | 0.85 | CA2 (0.61) | CA2CA1ALBFOLH1 | |
| SCHEMBL2246702 | 0.85 | MMP12 (0.60) | CA2CA1ALBMMP2MMP12 | |
| SCHEMBL2245609 | 0.84 | CA2 (0.66) | CA2CA1MMP2MMP9C3AR1 | |
| SCHEMBL2249747 | 0.82 | CA2 (0.63) | CA2CA1MMP2MMP9C3AR1 | |
| SCHEMBL4621821 | 0.82 | CA2 (0.63) | CA2CA1MMP2MMP9C3AR1 | |
| SCHEMBL2242569 | 0.82 | CA2 (0.63) | CA2CA1C3AR1KMT2A | |
| SCHEMBL2249692 | 0.81 | CA2 (0.62) | CA2CA1MMP2MMP9C3AR1 | |
| SCHEMBL2246916 | 0.81 | CA2 (0.58) | CA2CA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |