Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 6/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30233379 | 1.00 | LMNA (0.35) | LMNAMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL2804690 | 1.00 | LMNA (0.35) | LMNAMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL22470938 | 0.98 | SMN1; SMN2 (0.32) | LMNAMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL2255020 | 0.91 | — | — | |
| SCHEMBL8071432 | 0.88 | — | — | |
| SCHEMBL2655908 | 0.80 | ALDH1A1 (0.33) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8071294 | 0.79 | DNM1 (0.39) | MEN1KMT2ATSHRTHRBHTT | |
| SCHEMBL14673471 | 0.77 | ALDH1A1 (0.35) | ALDH1A1TSHR | |
| SCHEMBL14673799 | 0.77 | ALDH1A1 (0.35) | ALDH1A1TSHR | |
| SCHEMBL14673599 | 0.77 | ALDH1A1 (0.35) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111356687-B | Pyrimidine-containing tri-substituted imidazole compound and application thereof | 广州必贝特医药技术有限公司 | 2021-03-30 | — | — | CN | disclosed |
| WO-2020192302-A1 | PYRIMIDINE-CONTAINING TRI-SUBSTITUTED IMIDAZOLE COMPOUND AND APPLICATION THEREOF | 广州必贝特医药技术有限公司 | 2020-10-01 | — | — | WO | disclosed |
| CN-111356687-A | Pyrimidine-containing tri-substituted imidazole compound and application thereof | 广州必贝特医药技术有限公司 | 2020-06-30 | — | — | CN | disclosed |