Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22471069 | 0.96 | SIRT6 (0.46) | SIRT6POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22025605 | 0.91 | SIRT6 (0.48) | SIRT6POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29757768 | 0.91 | SIRT6 (0.48) | SIRT6POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22470985 | 0.91 | KDM4E (0.46) | POLBMAPTALDH1A1MAPK1TDP1 | |
| SCHEMBL22471057 | 0.90 | KDM4E (0.46) | POLBMAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL22470925 | 0.89 | MAPT (0.41) | SIRT6POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL12491627 | 0.88 | SIRT6 (0.56) | SIRT6POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL22471044 | 0.88 | ALDH1A1 (0.47) | POLBMAPTALDH1A1CYP2D6MAPK1 | |
| SCHEMBL22470970 | 0.88 | MAPT (0.41) | POLBMAPTALDH1A1MAPK1TDP1 | |
| SCHEMBL22471072 | 0.88 | MAPT (0.48) | POLBMAPTALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111356687-B | Pyrimidine-containing tri-substituted imidazole compound and application thereof | 广州必贝特医药技术有限公司 | 2021-03-30 | — | — | CN | disclosed |
| WO-2020192302-A1 | PYRIMIDINE-CONTAINING TRI-SUBSTITUTED IMIDAZOLE COMPOUND AND APPLICATION THEREOF | 广州必贝特医药技术有限公司 | 2020-10-01 | — | — | WO | disclosed |
| WO-2020192302-A1 | PYRIMIDINE-CONTAINING TRI-SUBSTITUTED IMIDAZOLE COMPOUND AND APPLICATION THEREOF | 广州必贝特医药技术有限公司 | 2020-10-01 | — | — | WO | disclosed |
| CN-111356687-A | Pyrimidine-containing tri-substituted imidazole compound and application thereof | 广州必贝特医药技术有限公司 | 2020-06-30 | — | — | CN | disclosed |