SCHEMBL22471127

SCHEMBL22471127

CSc1nccn1-c1ccc(F)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.62
NR4A2 P43354 1/20 0.62
TP53 P04637 1/20 0.50
THRB P10828 1/20 0.50
SMN1; SMN2 Q16637 4/20 0.46
GAA P10253 3/20 0.46
LMNA P02545 2/20 0.46
GFER P55789 1/20 0.46
L3MBTL1 Q9Y468 5/20 0.44
CYP1A2 P05177 5/20 0.44
CYP3A4 P08684 5/20 0.44
CYP2C9 P11712 5/20 0.44
CYP2C19 P33261 5/20 0.44
CYP2D6 P10635 4/20 0.44
ALOX15B O15296 3/20 0.44
MAPT P10636 2/20 0.42
MAPK13 O15264 2/20 0.42
MAPK12 P53778 2/20 0.42
MAPK11 Q15759 2/20 0.42
MAPK14 Q16539 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25545138 0.83 TP53 (0.57) NR4A1NR4A2TP53THRBSMN1; SMN2
SCHEMBL6163018 0.82 NR4A1 (0.62) NR4A1NR4A2TP53THRBSMN1; SMN2
SCHEMBL11387701 0.82 NR4A1 (0.67) NR4A1NR4A2TP53THRBSMN1; SMN2
Hydrochloric Acid SCHEMBL7106603 0.81 NR4A1 (0.60) NR4A1NR4A2TP53THRBSMN1; SMN2
Hydrochloric Acid SCHEMBL11387397 0.78 NR4A1 (0.57) NR4A1NR4A2TP53THRBSMN1; SMN2
SCHEMBL24943943 0.78 L3MBTL1 (0.61) TP53THRBSMN1; SMN2GAALMNA
SCHEMBL14156189 0.77 NR4A1 (1.00) NR4A1NR4A2TP53THRBSMN1; SMN2
SCHEMBL10901719 0.76 ALDH1A1 (0.61) GAACYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL24943934 0.73 L3MBTL1 (0.77) TP53THRBSMN1; SMN2GAALMNA
SCHEMBL6608437 0.72 NOTUM (0.41) TP53THRBSMN1; SMN2GAALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020192302-A1 PYRIMIDINE-CONTAINING TRI-SUBSTITUTED IMIDAZOLE COMPOUND AND APPLICATION THEREOF 广州必贝特医药技术有限公司 2020-10-01 WO disclosed