Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30524109 | 1.00 | MDM4 (0.49) | MDM4TP53MDM2KMT2APTPN1 | |
| SCHEMBL2252014 | 0.91 | MDM4 (0.47) | MDM4TP53KMT2APTPN1TLR2 | |
| SCHEMBL29989986 | 0.90 | KMT2A (0.52) | MDM4TP53MDM2KMT2APTPN1 | |
| SCHEMBL29792137 | 0.90 | KMT2A (0.52) | MDM4TP53MDM2KMT2APTPN1 | |
| SCHEMBL27728772 | 0.90 | MDM4 (0.49) | MDM4TP53MDM2KMT2ATLR2 | |
| SCHEMBL29591196 | 0.90 | KMT2A (0.52) | MDM4TP53MDM2KMT2APTPN1 | |
| SCHEMBL5323666 | 0.90 | KMT2A (0.52) | MDM4TP53MDM2KMT2APTPN1 | |
| SCHEMBL30074491 | 0.90 | KMT2A (0.52) | MDM4TP53MDM2KMT2APTPN1 | |
| SCHEMBL1709129 | 0.90 | KMT2A (0.52) | MDM4TP53MDM2KMT2APTPN1 | |
| SCHEMBL29350883 | 0.90 | KMT2A (0.52) | MDM4TP53MDM2KMT2APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105254537-A | Preparation method of Nalpha-fluorenylmethoxycarbonyl-glutamine tert-butyl ester | SHANGHAI GL POLYPEPTIDE CO LTD | 2016-01-20 | — | — | CN | disclosed |
| CN-105254537-A | Preparation method of Nalpha-fluorenylmethoxycarbonyl-glutamine tert-butyl ester | SHANGHAI GL POLYPEPTIDE CO LTD | 2016-01-20 | — | — | CN | disclosed |
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| EP-1781807-B1 | FLUORESCENCE-BASED KINETIC DETERMINATION OF TRANSGLUTAMINASE ACTIVITY | N ZYME BIOTEC GMBH (DE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007051604-A2 | NOVEL 2,4-DICHLOROPHENOXY ACETIC ACID DERIVATIVES AND USE THEREOF IN DIAGNOSTIC AND ANALYTIC DETECTION METHODS | FORSCHUNGSZENTRUM BORSTEL (DE) | 2007-05-10 | — | — | WO | disclosed |
| EP-1781807-A2 | FLUORESCENCE-BASED KINETIC DETERMINATION OF TRANSGLUTAMINASE ACTIVITY | N-Zyme BioTec GmbH (DE) | 2007-05-09 | — | — | EP | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
| WO-2006018164-A2 | FLUORESCENCE-BASED KINETIC DETERMINATION OF TRANSGLUTAMINASE ACTIVITY | N-ZYME BIOTEC GMBH (DE) | 2006-02-23 | — | — | WO | disclosed |
| EP-1626095-A1 | Fluorescence-based kinetic determination of transglutaminase activity | N-Zyme BioTec GmbH (DE) | 2006-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | MDM4 4353/4885TP53 4136/4885MDM2 2939/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | MDM4 4353/4885TP53 4136/4885MDM2 2939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.