Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cis-Urocanic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cis-Urocanic Acid SCHEMBL2245677 | 0.97 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSP90AA1OPRK1 | |
| Cis-Urocanic Acid SCHEMBL2242986 | 0.97 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSP90AA1OPRK1 | |
| Salicylic Acid SCHEMBL2250046 | 0.89 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSP90AA1OPRK1 | |
| Anthranilic Acid SCHEMBL2244669 | 0.87 | MAPT (0.38) | KDM4EALDH1A1HPGDHSP90AA1MAPT | |
| Anthranilic Acid SCHEMBL2245890 | 0.86 | MAPT (0.37) | KDM4EALDH1A1HPGDHSP90AA1MAPT | |
| Anthranilic Acid SCHEMBL2245820 | 0.86 | MAPT (0.37) | KDM4EALDH1A1HPGDHSP90AA1MAPT | |
| Cis-Urocanic Acid SCHEMBL2249970 | 0.83 | — | — | |
| Cis-Urocanic Acid SCHEMBL9614484 | 0.80 | — | — | |
| Cis-Urocanic Acid SCHEMBL2243934 | 0.80 | — | — | |
| Cis-Urocanic Acid SCHEMBL15419 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7993630-B2 | Protection of skin from UV and peroxide | BIODERM RESEARCH (US) | 2011-08-09 | — | — | US | claimed |
| US-20090269291-A1 | Protection of Skin from UV and Peroxide | BIODERM RESEARCH (US) | 2009-10-29 | — | — | US | claimed |
| US-7993630-B2 | Protection of skin from UV and peroxide | BIODERM RESEARCH (US) | 2011-08-09 | — | — | US | disclosed |
| US-20090269291-A1 | Protection of Skin from UV and Peroxide | BIODERM RESEARCH (US) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269291-A1 | Protection of Skin from UV and Peroxide | SOD3, UROD, SOD1 | KDM4E 3891/4885ALDH1A1 1367/4885HPGD 437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.