Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cis-Urocanic Acid SCHEMBL2245677 | 0.89 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2HSP90AA1 | |
| Cis-Urocanic Acid SCHEMBL2242986 | 0.89 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2HSP90AA1 | |
| Cis-Urocanic Acid SCHEMBL2247224 | 0.89 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2HSP90AA1 | |
| Anthranilic Acid SCHEMBL2243275 | 0.86 | MAPT (0.42) | KDM4EALDH1A1HPGDSMN1; SMN2NAPRT | |
| Cis-Urocanic Acid SCHEMBL2243934 | 0.82 | — | — | |
| Cis-Urocanic Acid SCHEMBL2243867 | 0.80 | L3MBTL1 (0.50) | KDM4EALDH1A1SMN1; SMN2NAPRTHSP90AA1 | |
| Cis-Urocanic Acid SCHEMBL2249970 | 0.79 | — | — | |
| Cis-Urocanic Acid SCHEMBL15419 | 0.79 | — | — | |
| Cis-Urocanic Acid SCHEMBL9614484 | 0.79 | — | — | |
| Cis-Urocanic Acid SCHEMBL2242360 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7993630-B2 | Protection of skin from UV and peroxide | BIODERM RESEARCH (US) | 2011-08-09 | — | — | US | claimed |
| US-20090269291-A1 | Protection of Skin from UV and Peroxide | BIODERM RESEARCH (US) | 2009-10-29 | — | — | US | claimed |
| US-7993630-B2 | Protection of skin from UV and peroxide | BIODERM RESEARCH (US) | 2011-08-09 | — | — | US | disclosed |
| US-20090269291-A1 | Protection of Skin from UV and Peroxide | BIODERM RESEARCH (US) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269291-A1 | Protection of Skin from UV and Peroxide | SOD3, UROD, SOD1 | KDM4E 3891/4885ALDH1A1 1367/4885HPGD 437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.