Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9237832 | 1.00 | TDP1 (0.49) | TDP1CASP3LMNATNFALDH1A1 | |
| SCHEMBL1256984 | 0.85 | TDP1 (0.46) | TDP1CASP3LMNATNFALDH1A1 | |
| SCHEMBL4909194 | 0.82 | TDP1 (0.44) | TDP1CASP3LMNATNFALDH1A1 | |
| SCHEMBL19615470 | 0.82 | TDP1 (0.50) | TDP1CASP3LMNATNFALDH1A1 | |
| SCHEMBL19981234 | 0.81 | TDP1 (0.53) | TDP1CASP3LMNAALDH1A1GAA | |
| SCHEMBL56405 | 0.81 | TDP1 (0.53) | TDP1CASP3LMNAALDH1A1GAA | |
| SCHEMBL28599364 | 0.80 | CES1 (0.49) | ALDH1A1GAA | |
| SCHEMBL11548706 | 0.80 | NR1H2 (0.44) | TDP1ALDH1A1GAAPOLBKDM4E | |
| SCHEMBL6364898 | 0.79 | TDP1 (0.52) | TDP1CASP3LMNATNFALDH1A1 | |
| SCHEMBL5490233 | 0.79 | TDP1 (0.52) | TDP1CASP3LMNATNFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632238-A | Thiacalix [4] arene mono-substituted amine Schiff base derivative and synthesis method thereof | 谢长江 | 2017-05-10 | — | — | CN | claimed |
| JP-8100129-A | — | — | None | — | — | JP | disclosed |
| US-11919880-B2 | HCV protease inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-03-05 | — | — | US | disclosed |
| US-11603570-B2 | Methods for the detection and treatment of leukemias that are responsive to DOT1L inhibition | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2023-03-14 | — | — | US | disclosed |
| CN-113735798-B | Preparation method of roxatidine acetate hydrochloride | 安徽美致诚药业有限公司 | 2022-07-12 | — | — | CN | disclosed |
| US-20220106290-A1 | HCV PROTEASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-04-07 | — | — | US | disclosed |
| CN-111875811-B | Supermolecule polymer and preparation method and application thereof | 常州大学 | 2022-02-11 | — | — | CN | disclosed |
| US-11197888-B2 | LHRH-platinum conjugates for treating reproductive cancers | Eastern Kentucky University (US) | 2021-12-14 | — | — | US | disclosed |
| CN-113735798-A | Preparation method of roxatidine acetate hydrochloride | 安徽美致诚药业有限公司 | 2021-12-03 | — | — | CN | disclosed |
| CN-107811971-B | Liposomes for drug delivery | 益普生生物制药公司 | 2021-10-29 | — | — | CN | disclosed |
| US-4537880-A | Aminopropylaminobleomycin derivatives and process for preparation thereof | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-08-27 | — | — | US | disclosed |
| EP-0150192-A1 | BICYCLIC BENZENOID AMINOALKYLENE ETHERS AND THIOETHERS. | RORER INT OVERSEAS (US) | 1985-08-07 | — | — | EP | disclosed |
| US-4529723-A | Gastrointestinal disorders; antiulcer agents | WILLIAM H. RORER, INC. (US) | 1985-07-16 | — | — | US | disclosed |
| WO-1984004247-A1 | BICYCLIC BENZENOID AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES | RORER INT OVERSEAS (US) | 1984-11-08 | — | — | WO | disclosed |
| EP-0024510-B1 | PHENOXYPROPYL AMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1983-10-19 | — | — | EP | disclosed |
| EP-0068806-A2 | Basic acyl amides of (5-amino-1,3-dialkylpyrazol-4-yl)(aryl)methanones, processes for their production, and pharmaceutical compositions containing such compounds | WARNER-LAMBERT COMPANY (US) | 1983-01-05 | — | — | EP | disclosed |
| US-4293557-A | AMIDES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1981-10-06 | — | — | US | disclosed |
| EP-0024510-A1 | Phenoxypropyl amine derivatives, process for their preparation, and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1981-03-11 | — | — | EP | disclosed |
| US-4038412-A | ANTI-VIRAL AGENTS | RICHARDSON-MERRELL INC. (US) | 1977-07-26 | — | — | US | disclosed |
| US-3937707-A | 6-SUBSTITUTED 1-PHENAZINOL 5,10-DIOXIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1976-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11603570-B2 | Methods for the detection and treatment of leukemias that are responsive to DOT1L inhibition | MLLT1, MCL1, BCR | TDP1 2018/4885CASP3 1726/4885LMNA 2534/4885 |
| US-11919880-B2 | HCV protease inhibitors | CTRL, HTR3C, PRSS1 | TDP1 2713/4885CASP3 572/4885LMNA 2531/4885 |
| US-20220106290-A1 | HCV PROTEASE INHIBITORS | CTRL, HTR3C, PRSS1 | TDP1 2713/4885CASP3 572/4885LMNA 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.