Sugi Predict

Sugi Predict / Compounds / SCHEMBL56405

SCHEMBL56405

SCHEMBL56405

CC(Br)N1C(=O)c2ccccc2C1=O

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.53
▸ LMNA P02545 2/20 0.52
▸ CASP3 P42574 1/20 0.48
▸ ALDH1A1 P00352 4/20 0.46
▸ HTT P42858 2/20 0.46
▸ TP53 P04637 2/20 0.45
▸ NPC1 O15118 1/20 0.45
▸ GAA P10253 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ MAPK1 P28482 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ MAPT P10636 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19981234 1.00 TDP1 (0.53) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL1892274 0.84 TDP1 (0.55) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL17916019 0.83 TDP1 (0.50) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL6656473 0.81 TDP1 (0.57) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL29381145 0.81 TDP1 (0.57) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL166122 0.81 TDP1 (0.57) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL2247257 0.81 TDP1 (0.49) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL9237832 0.81 TDP1 (0.49) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL1256984 0.78 TDP1 (0.46) TDP1LMNACASP3ALDH1A1HTT
SCHEMBL4197298 0.77 LMNA (0.56) TDP1LMNACASP3ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113694261-B Antibacterial composite coating and preparation method and product thereof 江苏百赛飞生物科技有限公司 2022-09-09 — — CN disclosed
CN-114437028-A Method for generating N-substituted phthalimide compound through nickel-catalyzed carbonylation reaction 桂林理工大学 2022-05-06 — — CN disclosed
CN-113698535-A Polymer, composition, coating thereof and product 江苏百赛飞生物科技有限公司 2021-11-26 — — CN disclosed
CN-113694261-A Antibacterial composite coating and preparation method and product thereof 江苏百赛飞生物科技有限公司 2021-11-26 — — CN disclosed
US-11141489-B2 Conjugates comprising an GLP-1/Glucagon dual agonist, a linker and hyaluronic acid SANOFI (FR) 2021-10-12 — — US disclosed
CN-113365984-A LOX inhibitors 癌症研究协会皇家癌症医院 2021-09-07 — — CN disclosed
CN-109641891-B Novel compounds and methods 维罗纳制药公司 2021-05-04 — — CN disclosed
US-10806797-B2 Prodrugs comprising an GLP-1/glucagon dual agonist linker hyaluronic acid conjugate SANOFI (FR) 2020-10-20 — — US disclosed
US-10792367-B2 Conjugates comprising an GLP-1/glucagon dual agonist, a linker and hyaluronic acid SANOFI (FR) 2020-10-06 — — US disclosed
US-10710998-B2 Compound and process VERONA PHARMA PLC (GB) 2020-07-14 — — US disclosed
US-4853407-A Aminoethylcysteine derivatives SANRAKU INCORPORATED (JP) 1989-08-01 — — US disclosed
WO-1989005811-A1 NEW 6-SUBSTITUTED MITOMYCIN ANALOGS UNIVERSITY PATENTS, INC. (US) 1989-06-29 — — WO disclosed
US-4697033-A INSECTICIDES SANDOZ LTD. (CH) 1987-09-29 — — US disclosed
US-4673684-A Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient TERUMO CORPORATION (JP) 1987-06-16 — — US disclosed
US-4604390-A FUNGICIDES, ANTITUMOR AGENTS WARNER-LAMBERT COMPANY (US) 1986-08-05 — — US disclosed
EP-0157420-A2 Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) 1985-10-09 — — EP disclosed
US-4542145-A Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides AMERICAN CYANAMID COMPANY (US) 1985-09-17 — — US disclosed
EP-0034894-B1 2-(1-PIPERAZINYL)-2,4,6-CYCLOHEPTATRIEN-1-ONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, INTERMEDIATES USED IN THE PROCESSES AND THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES AYERST, MCKENNA AND HARRISON INC. (CA) 1984-09-12 — — EP disclosed
US-4469694-A 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives AYERST, MCKENNA & HARRISON INC. (CA) 1984-09-04 — — US disclosed
EP-0034894-A2 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, processes for their preparation, intermediates used in the processes and the preparation thereof and pharmaceutical compositions containing the derivatives AYERST, MCKENNA AND HARRISON INC. (CA) 1981-09-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10792367-B2 Conjugates comprising an GLP-1/glucagon dual agonist, a linker and hyaluronic acid GLP1R, GIPR, GCGR TDP1 3189/4885LMNA 2029/4885CASP3 3447/4885
US-10806797-B2 Prodrugs comprising an GLP-1/glucagon dual agonist linker hyaluronic acid conjugate GLP1R, GIPR, GHSR TDP1 2906/4885LMNA 1265/4885CASP3 2203/4885
US-11141489-B2 Conjugates comprising an GLP-1/Glucagon dual agonist, a linker and hyaluronic acid GLP1R, GIPR, GCGR TDP1 3261/4885LMNA 1844/4885CASP3 3578/4885
US-10710998-B2 Compound and process RPL4, EIF5B, RPLP1 TDP1 2167/4885LMNA 2504/4885CASP3 4366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.