Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 5/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.36 |
| ▸ | CFTR | P13569 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 4/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17229732 | 0.93 | CREBBP (0.45) | CREBBPBRD4DPP4DPP7DPP8 | |
| SCHEMBL19297287 | 0.88 | RBP4 (0.38) | CREBBPBRD4DPP4DPP7DPP8 | |
| SCHEMBL19413422 | 0.87 | DPP4 (0.41) | CREBBPBRD4DPP4DPP7DPP8 | |
| SCHEMBL17232680 | 0.85 | CREBBP (0.40) | CREBBPBRD4DPP4DPP7DPP8 | |
| SCHEMBL17229760 | 0.85 | CREBBP (0.52) | CREBBPBRD4MAPK1PLA2G1BATG4B | |
| SCHEMBL17465959 | 0.84 | CREBBP (0.40) | CREBBPBRD4DPP4DPP7DPP8 | |
| SCHEMBL17229733 | 0.84 | CREBBP (0.40) | CREBBPBRD4DPP4DPP7DPP8 | |
| SCHEMBL17229758 | 0.83 | CGAS (0.42) | CREBBPBRD4CFTRMAPK1PLA2G1B | |
| SCHEMBL17229725 | 0.82 | CREBBP (0.39) | CREBBPBRD4MAPK1PLA2G1BATG4B | |
| SCHEMBL17465960 | 0.81 | MAPK1 (0.47) | CREBBPBRD4MAPK1PLA2G1BATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | QDPR, DPYD, DHPS | CREBBP 2642/4885BRD4 1651/4885DPP4 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.