Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.50 |
| ▸ | PARP1 | P09874 | 6/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 4/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 3/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23865256 | 0.76 | MAP3K5 (0.46) | PARP10PARP1F7F3MAPKAPK2 | |
| SCHEMBL30935025 | 0.76 | PARP10 (0.52) | PARP10PARP1MAPKAPK2PARP11PDPK1 | |
| SCHEMBL30935221 | 0.68 | PARP10 (0.43) | PARP10PARP1MAPKAPK2PARP11HSP90AA1 | |
| SCHEMBL2619126 | 0.68 | PARP10 (1.00) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL31585995 | 0.68 | PARP10 (1.00) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL20489212 | 0.68 | MAP3K5 (0.49) | PARP10PARP1PARP11KDM4E | |
| SCHEMBL29978642 | 0.68 | MAP3K5 (0.49) | PARP10PARP1PARP11KDM4E | |
| SCHEMBL22473990 | 0.68 | PDE3B (0.51) | PARP10PARP1F7F3MAPKAPK2 | |
| SCHEMBL21706202 | 0.68 | MAP3K5 (0.35) | PARP10PARP1MAPK1 | |
| SCHEMBL7237286 | 0.67 | PARP10 (0.54) | PARP10PARP1F7F3PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3572401-B1 | ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | Fuijan Cosunter Pharmaceutical Co. Ltd. (CN) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787435-B2 | ASK1 inhibitor and preparation method and use thereof | MARK1, MAP3K1, MAP3K20 | PARP10 1849/4885PARP1 1865/4885F7 4552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.