Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 5/20 | 0.32 |
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | HTR2A | P28223 | 5/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21705962 | 0.81 | MAP3K5 (0.47) | MAP3K5 | |
| SCHEMBL20489212 | 0.74 | MAP3K5 (0.49) | MAP3K5PARP1PARP10 | |
| SCHEMBL29978642 | 0.74 | MAP3K5 (0.49) | MAP3K5PARP1PARP10 | |
| SCHEMBL29977623 | 0.68 | RORC (0.37) | MAP3K5 | |
| SCHEMBL22473936 | 0.68 | PARP10 (0.50) | MAPK1PARP1PARP10 | |
| SCHEMBL28380967 | 0.68 | PDE4D (0.30) | — | |
| SCHEMBL28614404 | 0.68 | PDE4D (0.30) | — | |
| SCHEMBL31195434 | 0.66 | HTT (0.52) | CLK4DYRK1BFYNDAPK3NTRK1 | |
| SCHEMBL10139776 | 0.66 | HTT (0.52) | CLK4DYRK1BFYNDAPK3NTRK1 | |
| SCHEMBL28383965 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115504986-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-111107848-B | Pharmaceutical composition containing amide derivatives, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-115504986-A | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-111094250-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-109983007-B | Amide derivative inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-11-05 | — | — | CN | disclosed |
| US-11136324-B2 | Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2021-10-05 | — | — | US | disclosed |
| US-20210032249-A1 | AMIDE DERIVATIVE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2021-02-04 | — | — | US | disclosed |
| CN-111107848-A | Pharmaceutical composition containing amide derivatives, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-05-05 | — | — | CN | disclosed |
| CN-111094250-A | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-05-01 | — | — | CN | disclosed |
| WO-2020030107-A1 | PHARMACEUTICAL COMPOSITION CONTAINING AMIDE DERIVATIVES, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032249-A1 | AMIDE DERIVATIVE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF | AADAC, CHUK, TFPI | MAP3K5 26/4885CLK4 1757/4885DYRK1B 2239/4885 |
| US-11136324-B2 | Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors | AIFM1, IRAK1, CASP1 | MAP3K5 14/4885CLK4 840/4885DYRK1B 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.