Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 4/20 | 0.31 |
| ▸ | HTR2C | P28335 | 4/20 | 0.31 |
| ▸ | HTR2B | P41595 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21754754 | 0.83 | CHRM5 (0.35) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL16118495 | 0.71 | HTR2A (0.38) | HTR6HTR2AHTR2CHTR2B | |
| SCHEMBL18798821 | 0.69 | CHRM5 (0.36) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL25796721 | 0.69 | HTR2A (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL18853873 | 0.68 | GRIA2 (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL21754753 | 0.66 | CHRM5 (0.34) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL31706518 | 0.65 | MAP3K14 (0.39) | HTR2AHTR2CHTR2B | |
| SCHEMBL15723615 | 0.63 | L3MBTL1 (0.41) | — | |
| SCHEMBL20952911 | 0.62 | CHRM5 (0.36) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL17232683 | 0.62 | CHRM5 (0.35) | CHRM5CHRM1CHRM3MCHR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | QDPR, DPYD, DHPS | CHRM5 388/4885CHRM1 1635/4885CHRM3 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.