Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23251431 | 0.85 | L3MBTL1 (0.43) | GABRA1GABRB2MAOBSLC6A2SLC6A4 | |
| SCHEMBL27265727 | 0.81 | SCN8A (0.41) | GABRA1GABRB2MAOBSLC6A2SLC6A4 | |
| SCHEMBL12648278 | 0.79 | SLC6A2 (0.43) | GABRA1GABRB2SLC6A2SLC6A4MAPT | |
| SCHEMBL16954651 | 0.78 | L3MBTL1 (0.40) | MAOBL3MBTL1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10435321 | 0.76 | KDM4E (0.41) | GABRA1GABRB2MAOBALDH1A1LMNA | |
| SCHEMBL28332418 | 0.75 | ALDH1A1 (0.42) | GABRA1GABRB2MAOBSLC6A2SLC6A4 | |
| SCHEMBL13794212 | 0.74 | MAOB (0.44) | MAOBMAPTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL28823867 | 0.74 | GABRA1 (0.38) | GABRA1GABRB2SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL11919265 | 0.74 | DHODH (0.41) | GABRA1GABRB2SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL11921128 | 0.74 | SCN8A (0.41) | NPSR1L3MBTL1ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2876108-B1 | COMPOUNDS OF CHIRAL AROMATIC SPIROKETAL DIPHOSPHINE LIGANDS, PREPARATION METHODS AND USES THEREOF | SHANGHAI INST ORGANIC CHEMISTRY CAS (CN) | 2020-09-30 | — | — | EP | disclosed |