Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15464354 | 0.80 | LMNA (0.51) | LMNAALDH1A1HPGDMCL1MAPT | |
| SCHEMBL15464819 | 0.71 | MCL1 (0.70) | LMNAALDH1A1HPGDMCL1MAPT | |
| SCHEMBL15464936 | 0.71 | MCL1 (0.51) | LMNAALDH1A1HPGDMCL1MAPT | |
| SCHEMBL23843383 | 0.69 | MCL1 (0.53) | LMNAALDH1A1HPGDMCL1MAPT | |
| SCHEMBL20424197 | 0.68 | LMNA (0.62) | LMNAALDH1A1HPGDMAPTSTAT3 | |
| SCHEMBL24425871 | 0.67 | MTNR1A (0.51) | LMNAALDH1A1HPGDMAPTTP53 | |
| SCHEMBL15465236 | 0.67 | ALDH1A1 (0.51) | LMNAALDH1A1HPGDMCL1MAPT | |
| SCHEMBL15464255 | 0.67 | ALDH1A1 (0.50) | LMNAALDH1A1HPGDMCL1MAPT | |
| SCHEMBL11504186 | 0.67 | MCL1 (0.58) | LMNAALDH1A1HPGDMCL1MAPT | |
| SCHEMBL17692431 | 0.66 | HCAR2 (0.46) | LMNAALDH1A1MAPTTSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2880028-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2020-09-30 | — | — | EP | disclosed |