Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591017 | 0.91 | MET (0.43) | METJAK2JAK1TYK2JAK3 | |
| SCHEMBL21167444 | 0.90 | CSF1R (0.46) | METJAK2JAK1TYK2JAK3 | |
| SCHEMBL22475667 | 0.78 | MET (0.57) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL22475669 | 0.77 | MET (0.41) | METPDE3BPDE3ACSF1RCYP2C9 | |
| SCHEMBL24590999 | 0.76 | MET (0.44) | METCSF1RPDE10A | |
| SCHEMBL21167604 | 0.76 | CSF1R (0.62) | METCSF1RFGFR1FGFR3FGFR2 | |
| SCHEMBL22475809 | 0.75 | MET (0.60) | METJAK2JAK3PDE3BPDE3A | |
| SCHEMBL21167599 | 0.74 | MET (0.60) | METJAK2JAK1TYK2JAK3 | |
| SCHEMBL21167564 | 0.73 | MET (0.59) | METPDE3BPDE3APDE4CPDE4D | |
| SCHEMBL24591095 | 0.73 | MET (0.40) | METPDE3BPDE3APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |