Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475846 | 0.91 | SYK (0.44) | SYKPDPK1KDRHDAC1CLK1 | |
| SCHEMBL21167571 | 0.88 | PIK3CD (0.43) | SYKPDPK1KDRHDAC1CLK1 | |
| SCHEMBL21167606 | 0.87 | SYK (0.41) | SYKKDRNPC1 | |
| SCHEMBL21167708 | 0.83 | SYK (0.53) | SYKKDRCLK1DYRK1ACLK4 | |
| SCHEMBL21167709 | 0.83 | SYK (0.42) | SYKKDRNPC1 | |
| SCHEMBL21167474 | 0.81 | SYK (0.48) | SYKKDRHDAC1NPC1MET | |
| SCHEMBL22475671 | 0.81 | MET (0.44) | SYKMET | |
| SCHEMBL19961116 | 0.81 | SYK (0.46) | SYKPDPK1KDRNPC1MET | |
| SCHEMBL21167464 | 0.81 | NPC1 (0.36) | SYKPDPK1KDRCLK1CLK2 | |
| SCHEMBL22754358 | 0.81 | SYK (0.47) | SYKKDRDYRK1ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |