Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.48 |
| ▸ | WNT3A | P56704 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167638 | 0.91 | SYK (0.46) | SYKHDAC3NPC1KDRMET | |
| SCHEMBL21167387 | 0.89 | SYK (0.48) | SYKWNT3AHDAC3NPC1SSTR3 | |
| SCHEMBL24591052 | 0.88 | SYK (0.46) | SYKWNT3ANPC1SSTR3KCNH2 | |
| SCHEMBL24591086 | 0.87 | NPC1 (0.47) | SYKHDAC3NPC1KDRMET | |
| SCHEMBL22754381 | 0.86 | SYK (0.47) | SYKWNT3AHDAC3NPC1KDR | |
| SCHEMBL21167804 | 0.86 | MET (0.47) | SYKHDAC3NPC1KDRHDAC1 | |
| SCHEMBL19961116 | 0.85 | SYK (0.46) | SYKWNT3AHDAC3NPC1KDR | |
| SCHEMBL21167476 | 0.85 | WNT3A (0.40) | SYKWNT3ANPC1SSTR3KCNH2 | |
| SCHEMBL21167571 | 0.85 | PIK3CD (0.43) | SYKHDAC3NPC1KDRHDAC1 | |
| SCHEMBL22754358 | 0.84 | SYK (0.47) | SYKHDAC3NPC1KDRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |