Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22754363 | 0.92 | SYK (0.45) | SYKHDAC4EP300MEF2DHDAC6 | |
| SCHEMBL22754291 | 0.87 | SYK (0.43) | SYKMETHDAC3NPC1HDAC4 | |
| SCHEMBL22754381 | 0.87 | SYK (0.47) | SYKMETHDAC3NPC1HDAC4 | |
| SCHEMBL21167638 | 0.85 | SYK (0.46) | SYKMETHDAC3NPC1RAB9A | |
| SCHEMBL22754391 | 0.85 | SYK (0.43) | SYKMETHDAC3NPC1HDAC4 | |
| SCHEMBL21167474 | 0.84 | SYK (0.48) | SYKMETHDAC3NPC1HDAC6 | |
| SCHEMBL22754334 | 0.82 | SYK (0.46) | SYKHDAC3HDAC6KDR | |
| SCHEMBL21167387 | 0.82 | SYK (0.48) | SYKMETHDAC3NPC1MAPT | |
| SCHEMBL22475896 | 0.82 | SYK (0.39) | SYKMETHDAC3NPC1HDAC4 | |
| SCHEMBL22754338 | 0.81 | SYK (0.43) | SYKMETHDAC3NPC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831073-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES | RHIZEN PHARMACEUTICALS S A (CH) | 2020-12-09 | — | — | EP | disclosed |